CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid
نویسندگان
چکیده
منابع مشابه
Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium
OBJECTIVE The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) βamyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease. We therefore assessed whether lower preoperative CSF Aβ/Tau ratio was associated with higher incidence and greater severity of postoperative delirium. METHODS One hundred and fifty three participants (71...
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Glutamic acid decarboxylase of 65 kDa (GAD65) antibodies have been reported in a variety of neurological disorders such as stiff-person syndrome (SPS), sporadic ataxia and some cases of epilepsy. Since the target is believed to be the cytoplasmic enzyme GAD65, the key enzyme of γ-aminobutyric acid (GABA) synthesis, the pathophysiological role of these antibodies is poorly understood. Here, we s...
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BACKGROUND Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients. METHODS In this cross-sectional study we measured soluble amyloid precursor proteins alpha and beta (sAPPalpha and sAPPbeta), amyloid beta fragment 1-42 (Abeta1-42), and total and hyperphosph...
متن کاملStudy of Cerebrospinal Fluid Tissue Transglutaminase , T - TAU , Amyloid Β 42 in Alzheimer ’ s Disease
Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...
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BACKGROUND The search for a biomarker of Alzheimer's disease (AD) pathology (amyloid-β (Aβ) and tau) is ongoing, with the best markers currently being measurements of Aβ and tau in cerebrospinal fluid (CSF) and via positron emission tomography (PET) scanning. These methods are relatively invasive, costly, and often have high screening failure rates. Consequently, research is aiming to elucidate...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2010
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2009.12.011